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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2012 December;14(4):155-7

language: Italian

Multiple cherry angiomas in a young patient as a possible dermatological manifestation of von Hippel-Lindau disease

Peccerillo F., Di Caterino P., Battarra V. C.

UOSD Dermatologia Oncologica e Chirurgia delle Neoformazioni Cutanee, Azienda Ospedaliera “Sant’Anna e San Sebastiano”, Caserta


Von Hippel-Lindau disease (mVHL) is an inherited autosomal dominant disorder caused by a germline mutation of the VHL gene, a tumor suppressor gene on the short arm of chromosome 3 (3p25-26), whose germline mutations lead to the development of different and multiple tumors with a clinical phenotype extremely variable from patient to patient. In approximately 5% of cases may be present dermatologic manifestations; malformations such as cherry angioma are most frequently found. The cherry angioma is commonly seen, especially on the back of elderly individuals, posing as a hemispheric red bright lesion. In this article is taken into consideration the presence of multiple cherry angiomas and their not usual locations in a young subject, as a possible indicator of an important syndrome like mVHL.

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