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A Journal on Dermatology
Esperienze Dermatologiche 2012 September;14(3):105-7
An uncommon association between neurofibromatosis type 1 and cutaneous melanoma
Miraglia E., Curatolo P., Rotunno R., Visconti B., Bruni C., Calvieri S., Giustini S.
Dipartimento di Medicina Interna e Specialità Mediche, Università di Roma “Sapienza”, Roma, Italia
The neurofibromatosis type 1 (NF1) is a rare autosomal dominant disease, characterized by the involvement of different organs and systems. Susceptibility to neoplastic transformation is the main feature of the disease with a probability from 3 to 4 fold greater than in the general population. The occurrence of cutaneous malignant melanoma in NF1 is rarely described, even though its incidence (0.1-5.4%) is greater than in the healthy population. We report a case of a 63-year-old female patient with NF1 who was referred to our institute for a pigmentary lesion whose histological examination deposed for melanoma.