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ESPERIENZE DERMATOLOGICHE

A Journal on Dermatology


Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
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Esperienze Dermatologiche 2012 September;14(3):97-103

Copyright © 2012 EDIZIONI MINERVA MEDICA

language: Italian

Filaggrin (and other scleroproteins) in immune-mediated skin diseases

Di Stanislao C., Flati G., Biamonte A. S.

UOC di Dermatologia – UOS Di Allergologia, ASL - 01 Avezzano, Sulmona, L’Aquila; PO S. Salvatore, Dipartimento di Medicina, L’Aquila


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Filaggrin is an essential scleroprotein in the formation of basophil keratohyalin granules, the development of the corneal lamellae and natural moisturizing factor responsible for skin hydration. Recent studies have associated filaggrin with several genetic loci and its role in causing immune-mediated skin disorders such as atopic dermatitis, photoallergies, and contact dermatitis. This article summarizes salient data on pathogenetic processes in which reduced filaggrin production is correlated with various skin conditions.

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