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Passarini B., Therianou A., Varotti E., Sgubbi P., Infusino S. D.
Dipartimento di Medicina Interna, dell’Invecchiamento e Malattie Nefrologiche, Sezione di Dermatologia, Alma Mater Studiorum Università, Bologna
Palmoplantar keratodermas can be divided into hereditary, acquired or secondary and palmoplantar keratodermas in genodermatoses. Palmoplantar keratodermas represents a heterogeneous group of inherited skin diseases characterized by a focal or diffuse thickening of the stratum corneum of palmar and plantar surfaces. The division of inherited palmoplantar keratodermas is complex and can be summarized according to different criteria: mode of inheritance (autosomal dominant or autosomal recessive), clinical features of the hyperkeratosis (diffuse, nummular, linear, punctate), histological features (epidermolytic or not epidermolytic forms), the association or not with other diseases. Palmoplantar skin manifestations can be found in the course of different dermatosis such as for example, lichen planus, mycoses, pityriasis rubra pilaris, psoriasis, eczema, syphilis, keratoderma blenorrhagicum. In these cases, the palmoplantar keratoderma may constitute the only expression of dermatoses, but is more often associated with the presence of cutaneous manifestations localized in other body site. Palmoplantar keratodermas may be sometimes associated with some genodermatoses. Some examples are: Darier’s disease, porokeratosis of Mibelli, dyskeratosis congenita X-linked (Zinsser-Engman syndrome-Cole), epidermodysplasia verruciformis, basal cell nevus syndrome (Gorlin-Goltz syndrome). The histopathological features of these palmoplantar keratodermas are extremely variable, ranging from paintings very characteristic as in the case of Darier’s disease and porokeratosis of Mibelli to other histologically less specific as for example in Gorlin syndro