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A Journal on Dermatology
Esperienze Dermatologiche 2012 June;14(2):69-71
Cyclosporine and pregnancy in a psoriasic patient and review of the literature
Magnano M., Sgubbi P., Tengattini V., Bardazzi F., Patrizi A.
Sezione di Dermatologia, Dipartimento di Medicina Interna, dell’Invecchiamento e Malattie Nefrologiche, Università di Bologna, Bologna, Italia
There are few cases in literature about pregnant women treated with immunosuppressive drugs and, among them, patients treated with cyclosporine are even less. There are no reports so far describing the occurrence of pregnancy during cyclosporine treatment for psoriasis. We report the case of a 31-year-old woman affected by moderate-severe psoriasis, who had started the treatment with cyclosporine and, after four months of therapy, told us that she became pregnant. We decided to stop the systemic treatment and continue only a topical therapy. This choice was taken according to the Food and Drug Administration guidelines, which recommend the use of cyclosporine only in selected cases. Furthermore, it is known that pregnancy can improve psoriasis. Although the patient had taken cyclosporine during the first trimester of pregnancy, the fetus did not show any abnormalities. The delivery and the first year of development of the child have been regular. We suggest to update national and international registries about postmarketing phases of drugs for the special population of pregnant women.