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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2012 March;14(1):35-8


language: Italian

A “peel off” facial mask with 20% L-ascorbic acid stabilized by β-cyclodextrin and hyaluronic acid in severe photodamage

Cantù A. M., Rigoni C., Pabisch S., Atzori L., Barba A., Belloli C., Bertazzoni M., Brambilla L., Brazzelli V., Cannavò S. P., Capezzera R., Ciuffreda A., Cocciò G., Curia S., Dall’Oglio F., Fabbrocini G., Foti C., Ghersetich I., Mazzola G., Schena D., Strumia R., Tedeschi A., Tosti A., Vincenzi C., Zane C.

Associazione Donne Dermatologhe Italia


Skin photodamage and skin cancer are the result of acute and chronic exposure to ultraviolet radiation. In particular, chronic exposure to ultraviolet type B, and to a lesser extent type A, is believed to be largely responsible for the development of precancerous lesions such as actinic keratosis and hyperpigmentation. Skin photodamage clinically manifests itself as deep and fine wrinkles, xerosis and scaling, alteration of skin texture with laxity and reduced elasticity, pigment disorders and telangiectasia. A multicentre observational study was conducted on a group of patients (169) suffering of severe photodamage (Glogau classification of type 3 and type 4) in order to evaluate the results obtained by applying a polyvinyl mask containing 20% L-ascorbic acid stabilized with β-cyclodextrin and hyaluronic acid. Such a combination determined a controlled release and better penetration of the ascorbic acid, carrying out an effective moisturizing and antioxidant activity. The use of the mask with vitamin C led to a visible and statistically significant clinical improvement in patients with photoaging.

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