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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2012 March;14(1):29-34

language: Italian

Clinical evaluation of the efficacy of a new retinoic-complex (Retinsphere®) product for the treatment of skin photoaging

Cameli N., Mariano M., Abril E., Berardesca E.

Istituto Dermatologico San Gallicano, Roma, Italia


Aim. The aim of this study was to assess the efficacy and safety of a product containing a new retinoic complex (hydroxypinacolone retinoate and retinol, associated with papain, Maca andina, Cupressus sempervirens, moisturizing complex, folic acid and vitamin E) for the treatment of photoaged skin.
Methods. The study included ten female patients (age 28-81 years) with photoaged skin classified with the Glogau scale. Treatment consisted of applying the product twice daily for 8 weeks together with a topical photoprotector. No sun-exposure or artificial-UV exposure was admitted. Wrinkles, skin elasticity, tonicity, brightness, pigmentation and xerosis have been clinically evaluated at the time of enrolment (T0), after 4 weeks of treatment (T4), after 8 weeks (T8) and after 12 weeks from the beginning of treatment. Polarized and UV light photography (VISIA) have been performed. During the last visit patients’ opinion about efficacy and safety of the product has been asked.
Results. Analyzing the evaluation of clinical efficacy parameters for the treatment, a significative improvement of all the observed characteristics has been recorded. Also the global skin photoaging evaluation, performed at the times T0 and T12 with the Glogau scale, showed a significative improvement (P<0.001). Patients’ opinion about efficacy, safety and cosmetic acceptance of the treatment expressed during the last visit indicated a significative improvement in most cases.
Conclusion. A topical treatment, such as that used in this study, may provide a valid therapeutic aid in treating photoaged skin, as has indeed been shown by our results.

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