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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2012 March;14(1):25-8

language: Italian

Efficacy assessment of the association between two retinoids in the treatment of mild-moderate acne

Fabbrocini G., Cacciapuoti S.

Sezione di Dermatologia Clinica, Allergologica e Venereologica, Dipartimento di Patologia Sistematica Università di Napoli Federico II, Napoli, Italia


Aim. Different therapeutic options have shown to be effective in mild and moderate acne. Recently, association of topical retinoids has been proposed for the treatment of mild and moderate acne using a glycosphere technology. The aim of this study was to evaluate efficacy, safety and tolerability of a new association of two topical retinoids in the treatment of mild acne vulgaris.
Methods. Twenty subjects (9F/11M) (mean age: 30, range 18-40 yrs) with mild to moderate acne were treated with an association of hydroxypinacolone retinoate, a new retinoid, and retinol entrapped into glycosphere technology, containing papain, R-NMF (rebuilt-natural moisturizer factor), tocopherol (vitamin E), aloe barbadenis. Efficacy and safety evaluations were performed at baseline (T0), and after 60 days of therapy (T2). Treatment efficacy was evaluated by Global Acne Grading System. In a subset of 10 subjects follicular biopsy have been performed at T0 and T2.
Results. Most patients had satisfactory therapeutic response with a reduction of GAGS global score of 70% and a significant reduction of macro- and microcomedones.
Conclusion. These data suggest that this association can be considered a new option, quite effective and safe, in mild to moderate acne treatment.

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