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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2012 March;14(1):15-7

language: English

Chronic B-cell lymphocytic leukemia initially presenting with multiple cutaneous lesions: report of an unusual initial manifestation

Albayrak M. 1, Albayrak A. 2, Coban I. 3, Celebi H. 1, Alper M. 2, Unver Koluman B. 1

1 Department of Hematology, Diskapi Y.B. Training and Research Hospital, Ankara, Turkey
2 Department of Pathology, Diskapi Y.B. Training and Research Hospital, Ankara, Turkey
3 Department of Pathology, Hakkari State Hospital, Ankara, Turkey


Chronic lymphocytic leukemia (CLL) cases initially presenting with cutaneous involvement are unusual and most of these cases are T-cell CLL. We present a patient with persistent, pruritic, erythematous rash. Microscopic examination of skin biopsy was evaluated as the cutaneous involvement of a B-cell CLL/ small lymphocytic lymphoma. After interpreting the complete blood count, flow cytometry and the bone marrow biopsy, the patient was diagnosed as B-cell CLL presenting with cutaneous involvement. The patient was considered in the low-risk category according to the Modified Rai Staging system and was treated with a combination chemotherapy of cyclophosphamide, vincristine and prednisone (CVP). Cutaneous lesions disappeared after initiating the chemotherapy of six courses of CVP. The patient has been followed in remission since the last three years. We present this case as a rare patient with B-cell type CLL initially presenting with skin lesions, we also mentioned the response to the treatment.

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