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A Journal on Dermatology


Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
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Esperienze Dermatologiche 2011 December;13(4):193-5

language: Italian

The antiphospholipid syndrome: a case report

Rossi E. 1, Tavecchio S. 2, Balice Y. 2, Crippa D. 1

1 Unità Operativa Struttura Complessa di Dermatologia, Azienda Ospedaliera San Gerardo, Monza, Italia
2 Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italia


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The antiphospholipid syndrome is a disorder characterized by a triad of typical symptoms: high risk of arterial and/or vein thrombosis in any area of the body, early and recurrent abortions and thrombocytopenia. It is carachterized by a constant presence of circulating antiphospholipid antibodies, among which the best known are the anticardiolipin antibodies, IgG and IgM, and lupus anticoagulant. Cutaneous manifestation are often not specific, but the discovery of small vascular thrombosis can lead to the diagnosis, especially if a biopsy is performed on the painful nodules or on the edges of the ulcers. We can also found changes like those observed in the stasis dermatitis as hemosiderin deposits, thickening of the vessel walls, fibrosis. The main purpose of therapy is prevention of thrombotic recurrences with the use of anticoagulants, heparin and ASA. The authors describe a case of antiphospholipid antibody syndrome in a young patient with a nonspecific lesion in the left foot.

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