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A Journal on Dermatology
Esperienze Dermatologiche 2011 September;13(3):137-40
language: English, Italian
Pitted keratolysis: report of two cases successfully treated with topical clindamycin 1%
Piccolo V., Russo T., Baroni A.
Unità Operativa Complessa di Dermatologia e Venereologia - Seconda Università degli Studi di Napoli, Napoli
Pitted keratolysis (PK) (o keratolysis sulcata plantaris) is a juvenile plantar dermatosis caused by Corynebacterium spp., making the skin to assume a pitted aspect; the microorganism proliferates in stratum corneum and produces keratin-degrading enzymes, such as serine proteases P1 and P2, responsible of superficial stratum corneum dissolution. Diagnosis is possible due to clinical findings, that are extremely characteristic, even if it has been recently reported the adjuvant diagnostic role of dermoscopy. It is necessary to make differential diagnosis with mosaic plantar warts and tinea pedis. We report 2 cases of CPE, successfully treated with topic 1% clindamycin, resume all recent acquisitions in literature about this skin disease and propose a general scheme for prevention of CPE in patients affected by plantar hyperhidrosis.