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ESPERIENZE DERMATOLOGICHE

A Journal on Dermatology


Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
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Esperienze Dermatologiche 2011 March;13(1):29-32

language: English, Italian

Small nodular sarcoidosi: description of a clinical case

Spataro A., Melis L., Pala S.

Gli autori presentano un caso di sarcoidosi a piccoli noduli, variante inconsueta di una rara patologia multisistemica, caratterizzata dalla comparsa di granulomi epitelioidi non caseificanti negli organi in cui è presente il sistema istiocitario. Inoltre, viene considerata l’importanza della diagnostica differenziale con altre dermatosi di simile morfologia per l’evoluzione della patologia, potenzialmente coinvolgente altri organi e apparati.


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The authors present a case of small nodular sarcoidosis, an unusual variant of a rare multisystem disorder, characterized by the formation of non-caseating epithelioid granulomas in histiocytic system hosting organs, because of overactive Th1 immunological response to unknown antigen. Lung involvement is very frequent; the skin location of the disease is observed in 40-50% of patients. For the evolution of the disease, potentially involving other organs and systems, the importance of differential diagnosis with other morphologically similar dermatoses is also considered.

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