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A Journal on Dermatology
Esperienze Dermatologiche 2010 December;12(4):197-200
language: English, Italian
Chemical leukoderma: a report of 4 cases
Vozza A., Piccolo V., Di Girolamo F., Vozza G.
Seconda Università di Napoli, Facoltà di Medicina e Chirurgia, Cattedra di Dermatologia e Venereologia, Polo di Caserta, Caserta, Italia
Chemical leukoderma mimics vitiligo and arises after chronic exposure to specific chemical compounds (phenolic and catecholic derivatives) with demonstrated cytotoxicity to melanocytes. Tyrosinase-related protein-1 facilitates cytotoxicity by catalytic conversion of the compounds, resulting in the generation of radical oxygen species. This report describes 4 cases of chemical leukoderma, 2 caused by contact with personal accessories and 2 caused by occupational exposure to chemicals.