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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2010 June;12(2):89-93

language: English, Italian

Successful cyclosporine therapy in the course of leukocytoclastic vasculitis associated with the myelodysplastic syndrome

Panniello G. 1, Di Serio C. 1, Condello M. A. 1, Altobella A. 1, Goffredo A. 1, Castriota M. 2, Fenizi G. 1

1 Struttura Complessa di Dermatologia, Azienda Ospedaliero-Universitaria “OO.RR.”, Foggia
2 Servizio di Anatomia ed Istologia Patologica Ospedaliera, Azienda Ospedaliero-Universitaria “OO.RR.”, Foggia


Cutaneous vasculitis may have different causes, including infections, autoimmune disorders, adverse drug reactions, neoplasias (frequently hematological in nature). We present the case of a 69-year-old woman with the myelodysplastic syndrome and hypertension who came to our observation because of the appearance of livedo reticularis on the anterior aspect of the legs, accompanied by painful and tender nodular-ulcerative lesions. The clinical features, diagnostic and laboratory findings, and microscopic examination were consistent with leukocytoclastic vasculitis. Cyclosporine therapy (4 mg/kg) resolved the symptoms in about 45 days, with remission of pain and recovery of her normal relational life. Both short- and long-term follow-up were deemed necessary due to the possible evolution to a more complex clinical condition.

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