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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2009 December;11(4);167-69

language: English, Italian

Desmoplastic fibroblastoma

Calista D. 1, Pierfelice D. 2, Bartolini D. 3

1 Unità Operativa di Dermatologia, Ospedale “M. Bufalini”, Cesena
2 Specialista in Dermatologia, ASL Teramo
3 Unità Operativa di Anatomia Patologica, Ospedale “M. Bufalini”, Cesena


Desmoplastic fibroblastoma, a rare fibrous tumor first described by Evans in 1995, most commonly develops in men over the age of 50 years. Despite its predilection for hypodermic sites of the extremities, it can arise in any skin area and involve the fascia and musculoskeletal structures. The tumor does not tend to metastasize and is usually managed with conservative surgical treatment. Prominent histopathological features are fusiform or stellate fibroblasts immersed in a fibromixoid stroma, rare mitotic figures, without necrosis. Immunohistochemistry reveals positive expression of vimentin and local anti-smooth muscle antibodies. Differential diagnosis includes collagen-producing proliferative myoblastic neoformations: desmoid tumor, low-grade fibromixoid sarcoma, tendon sheath fibroma, neurofibroma, elastofibroma, chronic nodular fascites. This case presentation reports on a 62-year-old man with desmoplastic fibroblastoma on the sole of the right foot.

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