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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2009 December;11(4):149-58

language: English, Italian

Epidermodysplasia verruciformis: the role of Human Papillomavirus, definition of the disease and case series

Zavattaro E. 1, Azzimonti B. 2, Dell’Oste V. 2, Celasco M. 1, Dianzani U. 3, Amantea A. 4, Gariglio M. 2, Leigheb G. 1

1 Dermatologic Clinic, “A. Avogadro” University of Piemonte Orientale, Novara, Italy
2 Microbiology and Virology, Department of Clinical and Experimental Medicine, “A. Avogadro” University of Piemonte Orientale, Novara, Italy
3 Immunology, Department of Medical Sciences, “A. Avogadro” University of Piemonte Orientale, Novara, Italy
4 IRCCS San Gallicano, Rome, Italy


Epidermodysplasia verruciformis (EV) is a rare inherited disease characterised by numerous flat warts and pityriasis versicolor-like lesions on the back of the hand, the torso and the face, and by multiple cutaneous neoplasms arising precociously in sun-exposed areas. It has been suggested that such tumours are due to the beta-Human Papillomavirus (HPV) infection. EV cases are very rare in the literature and diagnosis is mainly based on clinical features and a histologic examination. In the present case report, authors analysed four patients affected by EV and assessed the HPV infection present. The presence of multiple genotypes belonging to the beta genus has been identified in both lesional and non-lesional skin sites, especially in hair bulbs. In all patients HPV-5 was the predominant genotype. Moreover, the same viral genotypes were maintained over time.

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