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A Journal on Dermatology
Esperienze Dermatologiche 2009 March;11(1):7-10
language: English, Italian
Unusual clinical presentation of Dowling-Degos disease
Panetta C., Donati P., Cota C., Muscardin L., Amantea A.
Serivizio di Dermatopatologia, Istituto Dermatologico San Gallicano, IRCCS – Roma
This case report describes an unusual presentation in a 41-year-old woman of Dowling-Degos disease associated with acne conglobata. Physical examination revealed hyperpigmented coalescent patches in the skin folds and nodules and abscesses resembling acne conglobata in the axillae. Histology of a hyperpigmented patch demonstrated a characteristic feature of Dowling-Degos disease: hyperplasia of prolonged and anastomized epidermal ridges in a reticulate pattern associated with increased melanic pigment of the basal layer and pseudocysts. The rare copresentation of these conditions suggest a follicular proliferation defect that could predispose to the formation of occlusive acneiform lesions.