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A Journal on Dermatology

Journal of Istituto Dermatologico San Gallicano
Official Journal of the Associazione Dermatologi Ospedalieri Italiani - A.D.O.I.
Indexed/Abstracted in: EMBASE, Scopus



Esperienze Dermatologiche 2008 March;10(1):9-12

language: English, Italian

Langerhans’ cell histiocytosis

Calista D. 1, Riccioni L. 2, Cerbone L. 3

1 Unità Operativa di Dermatologia, Ospedale “M. Bufalini”, Cesena
2 Servizio di Anatomia Patologica, Ospedale “M. Bufalini”, Cesena
3 Centro Clinico Plinio, Ercolano, Napoli


Langerhans’ cell histiocytosis (LCH) encompasses a variety of rare reticuloendothelial diseases sharing a common anatomopathological picture characterized by monoclonal infiltration and proliferation of organ tissue by Langerhans’ cells. LCH presents with a wide clinical spectrum and with single or multiple organ involvement. The recent International Society for the Study of Histiocytosis classification groups LCH according to age at onset and distribution of sites, number of organs involved and organ dysfunction as follows:
1. localized, unifocal LCH involving one organ (single system involvement [SS-LCH]);
2. disseminated, multifocal LCH involving more than one organ (multiple system involvement [MS-LCH]).
This case report concerns a 44-year-old man with LCH of the skin, lungs and liver parenchyma.

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