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A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2017 Jul 11

DOI: 10.23736/S0392-0488.17.05575-4


language: English

The large spectrum of spitzoid tumours: a retrospective survival study

Paolo BROGANELLI 1, Simone RIBERO 1 , Ilaria CASTAGNO 1, Fulvio RICCERI 2, 3, Tommaso DEBOLI 1, Elena MARRA 1, Carlo TOMASINI 4, Carlotta SACERDOTE 2, Simona OSELLA-ABATE 5, Martina SANLORENZO 1, Pietro QUAGLINO 1, Maria T. FIERRO 1

1 Department of Oncology and Dermatology, City of Health and Science, University of Turin, Turin, Italy; 2 Unit of Cancer Epidemiology, Department of Medical Sciences, City of Health and Science, University of Turin, Turin, Italy; 3 Unit of Epidemiology, Regional Health Service ASLTO3, Grugliasco, Turin, Italy; 4 Department of Human Pathology and Oncology, City of Health and Science, University of Turin, Turin, Italy; 5 Section of Pathology and Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy


BACKGROUND: There is no universally-accepted classification of spitzoid tumours. This makes difficult to assign a correct diagnosis and select a treatment that minimises the risk of overestimating, or worse, underestimating, the malignant potential of these tumours. To describe the clinical-pathological and epidemiological features of spitzoid tumours, as well as to assess mortality in these patients.
METHODS: This retrospective cohort study looked at data on spitzoid tumours excised in 1999-2012 at the Dermatologic Clinic of the Turin University Hospital. Spitzoid melanoma specific survival curves were generated with the Kaplan-Meier method and compared using the log-rank test.
RESULTS: in this time period, 1663 lesion were described at the pathologic report as spitzoid. 262 were (15.75%) Spitz naevi, 307 (18.46%) Reed naevi, 827 (49.73%), 810 (48.71%) spitzoid dysplastic naevi, 17(1.02%) atypical spitzoid tumours, and 267 (16.06%) spitzoid melanomas. Median follow up time was 9 years. Out of the entire cohort only 24 patients died from melanoma. All of them received a diagnosis of spitzoid melanoma. None of the patients with a diagnosis of not melanoma spitz tumour died for melanoma during the follow up.
CONCLUSION: In the large mayority of the cases, spitz tumour should be considered as benign lesion and excised only if melanoma features are seen. The used clinical pathological classification avoid misdiagnoses, inappropriate treatment and the risk of death for melanoma.

KEY WORDS: Atypical Spitz tumour - Survival - Reed nevus - Spitz nevus - Spitzoid melanoma - Spitzoid tumour

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Publication History

Article first published online: July 11, 2017
Manuscript accepted: June 5, 2017
Manuscript revised: May 11, 2017
Manuscript received: January 10, 2017

Cite this article as

Broganelli P, Ribero S, Castagno I, Ricceri F, Deboli T, Marra E et al. The large spectrum of Spitzoid tumours: a retrospective survival study. G Ital Dermatol Venereol 2017 Jul 11. DOI: 10.23736/S0392-0488.17.05575-4

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