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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2017 May 16

DOI: 10.23736/S0392-0488.17.05435-9

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Dermatofibrosarcoma protuberans: when the age makes the difference

Giovanni PAOLINO 1, Dario DIDONA 2 , Ugo BOTTONI 3, Federico ROMANIELLO 1, Paola CORSETTI 1, Antonio G. RICHETTA 1 Stefano CALVIERI 1

1 Dermatological Clinic, La Sapienza­ Università di Roma, Rome, Italy; 2 First Division of Dermatology, Istituto Dermopatico dell’Immacolata, ­IRCCS, Rome, Italy; 3 Department of Dermatology, Università della Magna Graecia, Catanzaro, Italy


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BACKGROUND: Dermatofibrosarcoma protuberans is a malignant tumor that affects exclusively the skin. It is a low­ grade malignant tumor of subcutaneous tissues, characterized by a local recurrence but it seldom metastasizes. This study aims to evaluate the impact of different clinical parameters on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.
METHODS: A retrospective study of data including 17 cases of dermatofibrosarcoma protuberans (11 male, 6 female) retrieved from the files of the Dermatology Clinics of La Sapienza, University of Rome. We evaluated three clinical parameters (age, sex and anatomic site of the primary tumor) using the Kaplan­ Meier product and the log­rank test.
RESULTS: The results highlighted that patients with an age ≤ 49 years showed a median disease free survival of 36 months, while patients with an age ≥50 years of 4 months (p < 0.0003). In addition, performing Rank­ correlation, only the variable age (p< 0.0001) reached the statistical significance. Regarding overall survival, performing Rank­correlation only the variable age reached the statistical significance (p= 0.02).
CONCLUSIONS: Our data suggests that age has a statistically significant role on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.


KEY WORDS: Dermatofibrosarcoma - Disease-free survival - Neoplasm - Retrospective studies

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