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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Stefano VERALDI, Luisa C. ROSSI, Mauro BARBARESCHI
Department of Pathophysiology and Transplantation, University of Milan, IRCCS Cà Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy
Retinoic acid is a physiological compound of human blood. Blood levels range from 1.000 to 7.000 pg/ml (usually 1.500-5.000 pg/ml). Results of studies on absorption of topical retinoic acid in laboratory animals, although rather conflicting, demonstrate that it induces plasma concentrations which are well below concentrations caused by non teratogenic oral doses. In humans, minimal percutaneous absorption of tretinoin was observed after topical applications. Neither single dose nor long term treatment with topical tretinoin affect the endogenous levels of retinoic acid or its metabolites. Topical application of tretinoin at doses used in acne unlikely induces systemic effects. Although some clinical cases of suspected tretinoin-related embryotoxicity have been described, three prospective cohort studies clearly demonstrated the safety of topical tretinoin as embryotoxic agent.