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A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2016 Jul 5
Satellitosis and CD117 immunohistochemical expression correlates with poor outcome in thick vulvar melanoma
Rosa A. SALCEDO-HERNÁNDEZ 1, Leonardo S. LINO-SILVA 2, David ISLA-ORTIZ 1, José A. POSADA-TORRES 1, José G. CHANONA-VILCHIS 2, M. Delia PÉREZ-MONTIEL 2, José M. AGUILAR-ROMERO 3, Jorge A. DOMÍNGUEZ-RODRÍGUEZ 3, Ángel HERRERA-GÓMEZ 1
1 Surgical Oncology Department, Instituto Nacional de Cancerología, Sección XVI, Tlalpan, Mexico City, Mexico; 2 Anatomic Pathology, Instituto Nacional de Cancerología, Sección XVI, Tlalpan, Mexico City, Mexico; 3 Medicine School, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
BACKGROUND: Melanoma of the vulva is the second most common vulvar cancer after epidermoide carcinoma. Patients with the disease usually present with a late stage disease with a poor prognosis. The prognostic factors reported in previous studies are not homogeneous and it is no clear the clinical or pathogenic role of c-KIT expression this neoplasm. Breslow staging currently is the most accurate predictor factor.
METHODS: We performed a clinicopathological study with literature review to identify predictors of prognosis and survival in melanoma of the vulva and investigated the expression of c-KIT (by immunohistochemistry) in 10 patients from the Instituto Nacional de Cancerología (Mexico City, Mexico).
RESULTS: Ten patients were identified, all older women with delayed presentation, high stage disease and limited response to treatment. We identified 5 patients (50%) with c-KIT expression, four of them recurred (p=0.01) and ultimately 3 died (p=0.038). We identified a) Satellitosis and b) c-KIT expression as prognostic predictors for death.
CONCLUSIONS: We conclude that c-KIT expression is a valuable predictor of prognosis and survival, especially in tick (> 4 mm) melanoma.