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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2016 Apr 20
Pain evaluation in patients affected by cutaneous squamous cell carcinoma and actinic keratosis: an observational study
Emi DIKA, Sabina VACCARI, Pier A. FANTI, Bianca M. PIRACCINI , Alessia BARISANI, Carlotta BARALDI, Annalisa PATRIZI ✉
Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
BACKGROUND: Pain is a frequent symptom in cancer patients. The aim of our study was to evaluate the presence of pain in histopathologically diagnosed hypertrophic actinic keratosis (AKs) or cutaneous squamous cell carcinomas (SCCs).
METHODS: An observational study evaluating pain presence and intensity in skin cancer was performed, including patients affected either by SCC or by hypertrophic AKs. Pain intensity was assessed using the 11-point numeric rating scale, Ranging from 0 (absence of pain) to 10 (most intense pain). Both spontaneous pain and pressure-related pain intensity, due to local digital pressure, were evaluated.
RESULTS: In patients with SCC, spontaneous pain was present in 57.5% of the cases, while pressure-related pain was revealed in 80.0% of the cases. In hypertrophic AKs, spontaneous pain was detected only in 15.0% of the cases, while pressure-related pain was present in 25.0% of the cases. A statistically significant difference between the 2 groups was found in the evaluation of spontaneous and pressure-related pain values, these values being significantly higher in the SCC group. No significant correlations between the degree of inflammation, the histotype or invasiveness of SCCs, and the intensity of pain were found.
CONCLUSION: The recognition of pain as a symptom, more frequently associated with SCCs, might prove useful in the clinical practice. Further research is needed, in order to better understand and characterize pain associated with different skin neoplasms.