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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2016 Apr 01
Chronic hand eczema, a disease difficult to diagnose and classify: is IL-36α helpful?
Maria SCHIATTARELLA 1, Cataldo PATRUNO 1, Nicola BALATO 1, Luigi CANTA 2, Giuseppina CAIAZZO 1, Serena LEMBO 1, Matteo MEGNA 1, Fabio AYALA 1, Anna BALATO 1 ✉
1 Department of Dermatology, University of Naples Federico II, Naples, Italy; 2 Department of Plastic Surgery, University of Naples Federico II, Naples, Italy
BACKGROUND: Chronic hand eczema (CHE) is not a homogenous disease, necessitating complex differential diagnostics. Interleukin (IL)-1 family members are significantly up-regulated in ACD and psoriasis patients skin.
METHODS: The present study aims to deepen the knowledge about clinical assessment and characterization of patients affected by chronic hand dermatitis (CHD) as well as to investigate the role of possible biomarkers which may help in the diagnostic process. An observational case- control study was performed enrolling 30 CHD patients and 20 healthy controls. Each patient underwent detailed medical history, clinical examination, epicutaneous patch test, and lesional skin biopsies for histological and immunohistochemical analysis.
RESULTS: Patient history, clinical examination and patch testing led us to a final CHD characterization in only 8/30 subjects (26.7%). In the remaining subjects, clinical and histological features suggested a diagnosis of psoriasis in 9/22 (30%) and idiopathic chronic hand eczema (CHE) in 13/22 (43.3%). Trying to find a possible marker for the latter dermatosis, we analysed IL-1 family in all the recruited subjects. IL-1 members were increased in all conditions, but IL- 36α was the only analyzed cytokine able to characterize patients who end up with a diagnosis of idiopathic CHE.
CONCLUSIONS: In conclusion, we can assess that medical history and patch testing remain essential investigations in CHD patients even if not always sufficient to perform a final diagnosis. Moreover, IL-1 members are probably involved in CHE skin inflammation, with IL-36α being a possible future biomarker which might help in the complex diagnostic process of CHE.