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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Online ISSN 1827-1820
Dika E. 2, Fanti P. A. 1, Misciali C. 1, Vaccari S. 2, Crisman G. 2, Barisani A. 2, Baraldi C. 2, Ribero S. 3, Patrizi A. 2
1 Laboratory of Dermatopathology, Dermatology, University of Bologna, Italy;
2 Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy;
3 Dermatology, University of Turin, Italy
AIM: Actinic keratoses (AKs) are the most common type of keratinocytic lesions worldwide. The skin areas affected by the so called “field cancerization” harbor mutagenetic risks for the development of squamous cell carcinoma (SCC).
METHODS: We retrospectively investigated the histopathological reports and clinical charts of 672 patients affected by multiple AKs, presenting at least 5 years of follow-up. The frequency of Non-Melanoma-Skin-Cancers (NMSC) (SCCs and Basal Cell Carcinomas (BCCs)) and Malignant Melanomas (Mms), in patients affected by multiple AKs, were analyzed.
RESULTS: More than 40% of patients with a previous diagnosis of multiple AKs developed an NMSC (SCC or BCC), or an MM, during a follow-up period of 5 to 11 years. The risk of developing another skin malignancy appeared to be higher in the age range between 61 and 80 years. The relative risk of developing a BCC and/or an MM in patients with a previous AK diagnosis was found to be 4.52.
CONCLUSION: The presence of multiple AKs and “field cancerization” seems to be associated with a high risk not only of Non-Melanoma-Skin-Cancers, such as Squamous Cell Carcinomas and Basal Cell Carcinomas, but also of Malignant Melanoma. An adequate follow-up should be performed in these groups of patients.