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CURRENT ISSUEGIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014

Frequency: Bi-Monthly

ISSN 0392-0488

Online ISSN 1827-1820

 

Giornale Italiano di Dermatologia e Venereologia 2015 Sep 16

Electrochemotherapy in non-melanoma head and neck skin cancers: a three centers experience and literature review

Rotunno R. 1, Marenco F. 2, Ribero S. 2, Calvieri S. 1, Amerio P. 3, Curatolo P. 1, Quaglino P. 2

1 Dermatologic and Plastic Surgery Clinic of University of Rome "La Sapienza", Roma, Italy;
2 Dermatologic Clinic of University of Turin “Molinette”, Turin, Italy;
3 Dermatologic Clinic of University of Chieti-Pescara “Gabriele D’Annunzio”, Chieti, Italy

AIM: The main purposes of this study were to evaluate the efficacy of electrochemotherapy in head and neck tumours, to assess the local tumour control, the safety profile and its impact on the patients’ quality of life.
METHODS: This is a multicenter prospective, non-randomized phase II trial. This trial was carried out at the Dermatologic Clinic of University of Rome "La Sapienza", at the Dermatologic Clinic of University of Chieti and at the Dermatologic Clinic of University of Turin. 55 patients with head and neck cancers were recruited. The electrochemotherapy procedure was carried out according to the ESOPE guidelines. Statistical analyses were performed using Stata/SE12.0 Statistical Software.
RESULTS: A significant clinical response was achieved in 50/55 patients with 91% of objective response rate (OR). 33 of 55 patients showed a CR (60%); 17 treated patients had a PR (31%). A significantly higher CR rate was obtained in patients not previously treated by surgery (15/19; 79%), with respect to those with a previous excision of the tumour (14/30; 47%) (p=0.025). An additional parameter influencing response is represented by anesthesia: patients treated by ECT with general anesthesia were characterized by significantly higher CR rate (68%) than those treated with local anesthesia (27%) (p=0.014).
CONCLUSIONS: Our experience confirmed high efficiency in local tumour control, excellent toxicity profile, tissue preservation with good cosmetic and functional results, even with repeated applications. ECT can represent a first-line treatment in the local management of head and neck cancers.

language: English


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