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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2015 Jul 29
Merkel cell carcinoma arising on a pre-existing Bowen’s disease: is it just by chance?
Casari A. 1, Argenziano G. 2, Piana S. 3, Lallas A. E. 2, Moscarella E. 2, Lombardi M. 2, Raucci M. 2, Pellacani G. 1, Longo C. 2 ✉
1 Department of Dermatology, University of Modena and Reggio Emilia, Italy;
2 Skin Cancer Unit, Arcispedale Santa Maria Nuova- IRCCS, Reggio Emilia, Italy;
3 Pathology Unit, Arcispedale Santa Maria Nuova- IRCCS, Reggio Emilia, Italy
BACKGROUND: Merkel cell carcinoma (MCC) is a cutaneous carcinoma with neuroendocrine differentiation. It arises typically on sunexposed areas of elderly men as an asymptomatic, rapidly growing, red nodule. Although it is usually found as a solitary nodule, in almost one third of cases MCC may be associated with other malignancies such as basal cell or squamous cell carcinomas.
OBJECTIVE: Merkel cell carcinoma should be considered as differential diagnosis everytime we have a rapidly growing, red nodule, arising in an elderly patient with signs of sun-damage.
METHODS:We report a case of MCC developing in association with a pre-existing Bowen's disease.
RESULTS: The association between MCC and Bowen's disease is quite common and their area of occurence is usually a sun-exposed area.
CONCLUSIONS: Ultraviolet radiation contributes to the etiology of both the malignancies.