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A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2015 Jan 21

language: English

Anogenital giant seborrheic keratosis (GSK)

Wollina U. 1, Chokoeva A. 2, Tchernev G. 3, Heinig B. 4, Schönlebe J. 5

1 Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-­Friedrichstadt, Dresden, Germany;
2 Department of Dermatology and Venereology, Medical University of Plovdiv, Plovdiv, Bulgaria;
3 Policlinic for Dermatology and Venerology, Saint Kliment Ohriski University, Medical Faculty, University Hospital Lozenetz, Sofia, Bulgaria;
4 Center of Physical and Rehabilitative Medicine, Academic Teaching Hospital Dresden‐Friedrichstadt, Dresden, Germany;
5 Institute of Pathology “Georg Schmorl”, Academic Teaching Hospital, Dresden-­Friedrichstadt, Dresden, Germany


Seborrheic keratosis (SK) are very common benign epidermal tumors. Giant seborrheic keratosis (GSK) is a rare variant with clinical characteristics, which leads very often to misdiagnosis. A genital site of SK is very unusual clinical manifestation and although the cause is still unknown, current literature data point to a possible pathogenetic role of chronic friction and HPV infection. The rare genital localization makes Buschke-­Löwenstein tumor and verrucous carcinoma important differential diagnoses. GSK may also show some clinical features of a melanoacanthoma, which makes cutaneous melanoma as another possible differential diagnosis. The clinical diagnosis of genital GSK is often a very difficult one, because the typical clinical features of GSK disappear and the most common dermoscopic features of GSK are usually not seen in the genital region lesions. The diagnosis of GSK of the anogenital area should be made only and always after the exact histological verification and variety of differential diagnosis should be carefully considered. The treatment of GSK is primary surgically. We present a rare case of giant seborrheic keratosis (GSK) with concomitant HPV infection in the anogenital region of 72‐year­‐old patient. Surgical approach was performed with excellent outcome.

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