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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Giornale Italiano di Dermatologia e Venereologia 2017 August;152(4):383-6

DOI: 10.23736/S0392-0488.16.04945-2

Copyright © 2014 EDIZIONI MINERVA MEDICA

language: English

Anogenital giant seborrheic keratosis

Uwe WOLLINA 1 , Anastasiya CHOKOEVA 2, Georgi TCHERNEV 3, 4, Birgit HEINIG 5, Jacqueline SCHÖNLEBE 6

1 Department of Dermatology and Allergology, Dresden-Friedrichstadt Academic Teaching Hospital, Dresden, Germany; 2 Department of Dermatology and Venereology, Medical University of Plovdiv, Plovdiv, Bulgaria; 3 Department of Dermatology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR), Sofia, Bulgaria; 4 ‘Onkoderma’ - Polyclinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria; 5 Center of Physical and Rehabilitative Medicine, Dresden-Friedrichstadt Academic Teaching Hospital, Dresden, Germany; 6 Georg Schmorl Institute of Pathology, Dresden-Friedrichstadt Academic Teaching Hospital, Dresden, Germany


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Seborrheic keratosis (SK) are very common benign epidermal tumors. Giant seborrheic keratosis (GSK) is a rare variant with clinical characteristics, which leads very often to misdiagnosis. A genital site of SK is very unusual clinical manifestation and although the cause is still unknown, current literature data point to a possible pathogenetic role of chronic friction and HPV infection. The rare genital localization makes Buschke-Löwenstein tumor and verrucous carcinoma important differential diagnoses. GSK may also show some clinical features of a melanoacanthoma, which makes cutaneous melanoma as another possible differential diagnosis. The clinical diagnosis of genital GSK is often a very difficult one, because the typical clinical features of GSK disappear and the most common dermoscopic features of GSK are usually not seen in the genital region lesions. The diagnosis of GSK of the anogenital area should be made only and always after the exact histological verification and variety of differential diagnosis should be carefully considered. The treatment of GSK is primary surgically. We present a rare case of GSK with concomitant HPV infection in the anogenital region of 72-year-old patient. Surgical approach was performed with excellent outcome.


KEY WORDS: Seborrheic keratosis - Buschke-Löwenstein tumor - Male genital disease - Operative surgical procedures

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Publication History

Issue published online: June 14, 2017
Article first published online: January 21, 2015
Manuscript accepted: October 13, 2014
Manuscript received: September 22, 2014

Cite this article as

Wollina U, Chokoeva A, Tchernev G, Heinig B, Schönlebe J. Anogenital giant seborrheic keratosis. G Ital Dermatol Venereol 2017;152:383-6. DOI: 10.23736/S0392-0488.16.04945-2

Corresponding author e-mail

wollina-uw@khdf.de