Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Giornale Italiano di Dermatologia e Venereologia 2017 August;152(4) > Giornale Italiano di Dermatologia e Venereologia 2017 August;152(4):342-7

CURRENT ISSUE
 

ARTICLE TOOLS

Publication history
Reprints
Cite this article as

GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,311


eTOC

 

ORIGINAL ARTICLE  


Giornale Italiano di Dermatologia e Venereologia 2017 August;152(4):342-7

DOI: 10.23736/S0392-0488.16.05235-4

Copyright © 2016 EDIZIONI MINERVA MEDICA

language: English

Interleukin levels and macrophagic density in periumbilical fat tissue in patients affected by moderate-to-severe psoriasis with metabolic syndrome, before and after etanercept treatment

Alberico MOTOLESE 1 , Valeria CHIARAVALLOTI 1, Michele CERATI 2, Rita OLDRINI 2, Federica MOLA 1, Alberto PASSI 3

1 Department of Dermatology, Macchi Hospital, Varese, Italy; 2 Department of Histopathology, Macchi Hospital, Varese, Italy; 3 Department of Experimental and Clinical Biomedical Sciences, University of Insubria, Varese, Italy


PDF  


BACKGROUND: Psoriasis is a chronic inflammatory and immunological mediated skin disease characterized by epidermic proliferation, keratinocytes diversification disorder, excessive angiogenesis and immunological dysfunctions. Lately, the association of psoriasis with several comorbidities increased. Cardiovascular and metabolic disorders can be related to inflammatory conditions in which pro-inflammatory cytokines secreted by adipose tissue such as TNF-alpha increase. The aim of our study was to investigate the relation between abdominal adipose tissue inflammatory state and metabolic syndrome.
METHODS: Between January and June 2014 we selected 10 patients affected by moderate to severe psoriasis. Umbilical fat tissue biopsies were carried out before and after 24 weeks of treatment with TNF-alpha inhibitor (etanercept). Morphological parameters of macrophages were estimated using immunohistochemistry methods and hematoxilyn-eosin (H&E) coloration; IL-6 and TNF-alpha and IL1B were measured using molecular biology techniques.
RESULTS: After 24 weeks of treatment with TNF-alpha inhibitor (etanercept), a decrease of macrophages infiltration, inflammatory citokyne levels and gene expression were noticed.
CONCLUSIONS: The link between inflammatory status in umbilical fat tissue of patients affected by severe psoriasis and metabolic syndrome was confirmed.


KEY WORDS: Psoriasis - Etanercept - Metabolic syndrome X - Adipose tissue - Tumor necrosis factor-alpha

top of page

Publication History

Issue published online: June 14, 2017
Article first published online: June 10, 2016
Manuscript accepted: May 30, 2016
Manuscript revised: May 6, 2016
Manuscript received: October 5, 2015

Cite this article as

Motolese A, Chiaravalloti V, Cerati M, Oldrini R, Mola F, Passi A. Interleukin levels and macrophagic density in periumbilical fat tissue in patients affected by moderate-to-severe psoriasis with metabolic syndrome, before and after etanercept treatment. G Ital Dermatol Venereol 2017;152:342-7. DOI: 10.23736/S0392-0488.16.05235-4

Corresponding author e-mail

alberico.motolese@asst-settelaghi.it