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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Özlem BİLGİÇ 1, Ayhan BİLGİÇ 2, Abdullah SİVRİKAYA 3, Yavuz SELVİ 4, Ali ÜNLÜ 3, Hilmi C. ALTINYAZAR 1
1 Department of Dermatology, School of Medicine, Selcuk University, Konya, Turkey; 2 Department of Child and Adolescent Psychiatry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey; 3 Department of Biochemistry, School of Medicine, Selcuk University, Konya, Turkey; 4 Department of Psychiatry, School of Medicine, Selcuk University, Konya, Turkey
BACKGROUND: There is limited data concerning the relationship between psychosocial problems of psoriasis patients and the function of their hypothalamic-pituitary-adrenal (HPA) axis and immunologic markers. This study aimed to determine serum levels of basal cortisol and adrenocorticotropic hormone (ACTH) and circulating levels of various cytokines and chemokines and their association with psychological measures in psoriasis patients.
METHODS: Serum concentrations of endocrinological and immunological variables were quantified, and psychiatric questionnaires were completed.
RESULTS: In psoriasis patients, serum levels of ACTH, TNF-a, IL-6, IL-23, CCL-17, CCL-27, CCL-20 and CXCL-9, current psychiatric symptoms and childhood neglect scores were all higher than in controls. In addition, in psoriasis patients, physical neglect scores were related to lower basal cortisol, whereas recent stressful life events were related to higher IL-6, IL-23 and CCL-20 levels.
CONCLUSIONS: The exposure to stressful life events in childhood and just before a flare-up of psoriasis may be related to altered function of the HPA axis and an immune dysregulation in psoriasis.