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Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Cristaudo A. 1, Francesconi L. 1, Ambrifi M. 1, Frasca M. 1, Cavallotti C. 1, Sperduti E. 2
1 Operative Unit of Clinical Dermatology, Dermatological Institute, San Gallicano (IRCCS) Rome, Italy;
2 Unit of Biostatistics, Istituti Fisioterapici Ospitalieri - IFO, Rome, Italy
AIM: Xerosis cutis is a frequent condition in the elderly and the topical treatments are aimed to maintain a balance between
the physiological components of the epidermis and an optimal moisturization. The aim was to evaluate the efficacy
of a dermoprotective, glycerol and paraffin-based cream in the treatment of individuals affected by senile xerosis.
METHODS: The patients were recruited at the Professional Dermatology and Allergology Outpatient Clinic of the San Gallicano Dermatological Institute of Rome, between 1st January 2013 and 30th September 2014. To assess the efficacy of the cream, two different areas of treatment were identified in each patient’s limbs. All patients were staged at baseline (T0) and evaluated after 14 days (T1) and 28 days (T2) of topical
treatment, using five clinical parameters: scaling, sensation of skin tightness, presence of fissuring and excoriations from
scratching and erythema. The itching degree was also evaluated using a 10-step analogue scale.
RESULTS: Fifty patients with xerosis, 25 with a severe and 25 with a moderate form, over 60 years old were recruited and
evaluated. Median age was 65 years (IQR=61-70). After 28 day of topical administration of the cream, 54.0% of patients
showed the absence of signs of xerosis, 44.0% a mild form and 2.0% (one patient) a moderate form. Consistently, a progressive
and significative reduction of itching and transepidermal water loss (TEWL), and an improvement in skin hydration
was also measured. A good profile of tolerability and no episodes of undesirable side effects were observed.
CONCLUSION: The topical daily use of a glycerol and paraffin based cream seems to be able to control the xerosis in elderly
patients, with a significant reduction of all associated signs and symptoms. Further additional data should be collected to better confirm the role of the topical treatment in the control of disease.