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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2015 April;150(2):183-91
Cutaneous vasculitidis: histology and immunofluorescence
Filosa A. 1, Verdelli A. 2, Bianchi B. 2, Del Bianco E. 2, Bugatti L. 3, Filosa G. 3, Caproni M. 2 ✉
1 Operative Unit of Pathological Anatomy, ASUR Marche AV3 Macerata, Italy;
2 Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy;
3 Operative Unit of Dermatology, Carlo Urbani Hospital, ASUR Marche AV2 Jesi, Ancona, Italy
Cutaneous vasculitis comprises a wide spectrum of diseases that involve predominantly the blood vessels and surrounding tissues of the skin. Few vasculitic syndromes have pathognomonic clinical, radiographic and/or laboratory findings; thus, confident and accurate diagnosis of vasculitis requires histological confirmation. Skin biopsy should be done, optimally within 24 to 48 hours after vasculitic lesions appear. Deep excision biopsy must be preferred. Direct immunofluorescence of lesional skin is helpful in the diagnosis of vasculitides in the light of a proper clinico-pathological setting and diagnostic in some peculiarly forms.
Cutaneous histological patterns can be used to generate relevant clinical differential diagnoses, and, when coupled with patient’s history, clinical and laboratory data, allow more precise and accurate diagnosis of vasculitic syndromes. This review will focus on histopathological and immunologic pattern of the more common cutaneous vasculitis syndromes, based on the 2012 Revised International CHCC.