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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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  DRUG ERUPTIONS - Part II


Giornale Italiano di Dermatologia e Venereologia 2014 June;149(3):311-6

language: English

Inflammatory/infectious cutaneous side effects of biological drugs in patients with psoriasis: a general review with personal data

Rongioletti F. 1, 2, Burlando M. 1, 2, Parodi A. 1, 2

1 IRCCS, San Martino‑IST University Hospital, Genoa, Italy;
2 Section of Dermatology, DISSAL University of Genoa, Genoa, Italy


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In recent years, the use of biologic drugs has greatly changed the therapy of psoriasis and psoriatic arthritis, but they have some adverse effects. In particular, skin lesions induced by anti-tumor necrosis factor (TNF) and anti-interleukin (IL) 12/23 drug (ustekinumab) have been reported with an increased incidence, highlighting the importance of the skin as a major target of the side effects of these drugs. There is a wide spectrum of skin lesions of different morphology and etiology that includes skin lesions directly related to drug administration, the development of cutaneous immune-mediated conditions and cutaneous infections. The aim of this review is to revisit the literature data on inflammatory/infectious skin adverse effects of biologics both anti-TNF-α inhibitors and anti-IL 12/23 antagonists and to report and update our personal data on inflammatory/infectious side effects in patients with psoriasis/psoriatic arthritis treated with biologics.

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franco.rongioletti@unige.it