Advanced Search

Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Giornale Italiano di Dermatologia e Venereologia 2012 June;147(3) > Giornale Italiano di Dermatologia e Venereologia 2012 June;147(3):239-49

ISSUES AND ARTICLES   MOST READ   eTOC

CURRENT ISSUEGIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 0,491

Frequency: Bi-Monthly

ISSN 0392-0488

Online ISSN 1827-1820

Giornale Italiano di Dermatologia e Venereologia 2012 June;147(3):239-49

 

    REVIEWS

What genomics has taught me about melanocytic neoplasms

Leboit P. E.

Departments of Pathology and Dermatology, University of California, San Francisco, CA, USA

Recent advances in the molecular biology of melanocytic neoplasms have enabled what were previously investigational tools to be used for more accurate diagnosis of melanocytic neoplasms. These include fluorescence in situ hybridization, comparative genomic hybridization, and sequencing. Correlation with conventional histopathology and immunohistochemistry has led to a better understanding of the classification of melanocytic neoplasms, as well as to the idenfication of new clinicopathologic entities. Herein are illustrated some pitfalls in the diagnosis of melanoma, as well as variants of Spitz’s nevus that correlate with specific genomic aberrations such as gains of chromosome 11p and loss of the BAP-1 gene on chromosome 3p.

language: English


FULL TEXT  REPRINTS

top of page