Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Giornale Italiano di Dermatologia e Venereologia 2012 February;147(1) > Giornale Italiano di Dermatologia e Venereologia 2012 February;147(1):65-9

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014


eTOC

 

  PEARLS IN DERMATOLOGY


Giornale Italiano di Dermatologia e Venereologia 2012 February;147(1):65-9

language: English

New insights about delayed allergic hypersensitivity to corticosteroids

Baeck M. 1, Goossens A. 2

1 Departement of Dermatology, , Saint-Luc University Clinic, Louvain Catholic University, Bruxelles, Belgium;
2 Departement of Dermatology, University Hospital, Leuven Catholic University Hospital, Leuven, Belgium


PDF  


Corticosteroids are among the most commonly used drugs, both topically and systemically. Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. With regard to cross-reactions between corticosteroids, based on patch-test results and molecular modelling, we were recently able to simplify the previous classification into 3 different groups, i.e., Group 1: the non-methylated, most often non-halogenated molecules (Group A, D2 and budesonide), which produce most of the allergic reactions; Group 2: the halogenated molecules with a C16/C17 cis ketal/diol structure (acetonide Group B); and Group 3: the halogenated and C16-methylated molecules (Group C and D1) that only rarely produce allergy.

top of page

Publication History

Cite this article as

Corresponding author e-mail

an.goossens@uzleuven.be