Home > Journals > Giornale Italiano di Dermatologia e Venereologia > Past Issues > Giornale Italiano di Dermatologia e Venereologia 2011 February;146(1) > Giornale Italiano di Dermatologia e Venereologia 2011 February;146(1):17-30

CURRENT ISSUE
 

ARTICLE TOOLS

Reprints

GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014


eTOC

 

  PSORIASIS


Giornale Italiano di Dermatologia e Venereologia 2011 February;146(1):17-30

language: English

Role of the immune system and immunological circuits in psoriasis

Jabbari A. 1,2, Johnson-Huang L. M. 2, Krueger J. G. 2

1 The Ronald O. Perelman, Department of Dermatology, New York University School of Medicine
New York, NY, USA;
2 Laboratory for Investigative Dermatology, Rockefeller University, New York, NY, USA


PDF  


Psoriasis vulgaris is a chronic skin disease in which our understanding of the pathogenesis has substantially grown in recent years. Our current appreciation of the role of the immune system is that it plays a necessary and driving role in the disease process. Investigations into the genetics of psoriasis has spurred further examinations into the contributions of immune mediators such as IL-23, IL-17, IL-22, and TNF as well as cellular mediators including a variety of dendritic cell populations of the skin and the growing number of T cell types, including the Th17 and Th22 subsets. Investigations into how these soluble and cellular elements interact with each other and the skin and form complex signal circuits to engender the psoriasis phenotype is starting to become elucidated. Furthermore, these recent advances have been fruitful in leading to the development of new classes of biologic therapeutics that are remarkably effective in halting the disease process.

top of page

Publication History

Cite this article as

Corresponding author e-mail

jgk@rockefeller.edu