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A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014

Frequency: Bi-Monthly

ISSN 0392-0488

Online ISSN 1827-1820


Giornale Italiano di Dermatologia e Venereologia 2009 December;144(6):713-23



Italian guidelines and therapeutic algorithm for actinic keratoses

Rossi R. 1, Calzavara-Pinton P. G. 2, Giannetti A. 3, Peserico A. 4, Santucci M. 5, Vena G. A. 6, Lotti T. 7

1 Section of Dermatology II, University of Florence, Local Health Unit 10, Florence, Italy;
2 Department of Dermatology, University of Brescia, Brescia, Italy;
3 Dermatology Clinic, University of Modena, Modena, Italy;
4 Unit of Dermatology, University of Padua, Padua, Italy;
5 Department of Human Pathology and Oncology, University of Florence, Florence, Italy;
6 2nd Dermatology Clinic, University of Bari, Bari, Italy;
7 Section of Dermatology II
University of Florence, Florence, Italy

The prevalence of actinic keratosis (AK) continues to rise among white people throughout the world and it is necessary to increase the level of attention paid to it from a diagnostic and a preventive point of view. Today, AK must be considered an in situ squamous cell carcinoma and as such, must be managed using one of the available approved therapeutic alternatives. However, when multiple AKs develop on severely photodamaged skin, the treatment of the lesion together with that of the field of cancerization is part of an optimal strategy that aims not only to solve alterations clinically evident but also those in the surrounding skin field cancerization, that most likely hosts genetic alterations and is the site of initial gradual replacement of normal cells with tumoral cells. This paper reports the most recent evidences from a careful review of the literature’s key articles of the treatment of AKs and suggests guidelines for the clinicians. The guidelines indicated by the authors have also been based on practical evaluations and their own clinical experience. The present conclusions may be modified by new findings in the field of oncologic research.

language: English


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