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CURRENT ISSUEGIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014

Frequency: Bi-Monthly

ISSN 0392-0488

Online ISSN 1827-1820

 

Giornale Italiano di Dermatologia e Venereologia 2009 August;144(4):363-77

PEMPHIGUS AND PEMPHIGOID UPDATE IN 2009 

Treatment options for pemphigus foliaceus

Fernando S. L. 1,2,3, Broadfoot A. J. 2

1 Department of Clinical Immunology, Royal North Shore Hospital, Sydney, NSW, Australia
2 Department of Allergy, Royal North Shore Hospital, Sydney, NSW, Australia
3 Northern Clinical School, University of Sydney,NSW, Australia

Pemphigus foliaceus belongs to a group of rare autoimmune blistering mucocutaneous conditions. Systemic corticosteroids have markedly reduced the mortality from the disease but its utility is restricted by adverse events. This is further complicated by the fact that steroid-sparing agents are also associated with serious adverse events and there are only few randomized controlled trials demonstrating a beneficial response from the use of these agents. Azathioprine and mycophenolate mofetil appear to be the most feasible first line adjunctive agents in terms of inducing and maintaining remission and harboring a comparatively favourable side effect profile. An enhanced understanding of the pathogenesis of pemphigus has resulted in the implementation of a number of novel therapies including biological agents, intravenous immunoglobulin, and extracorporeal treatment modalities. These therapies have also been mainly studied through case series reports, are expensive and/or difficult to access in some centres, and are associated with a number of deleterious side effects. Rituximab, the anti-CD20 chimeric monoclonal antibody, is currently emerging as the therapy of choice in severe refractory disease. Further studies on the effects and safety profiles of more specific agents, such as peptide immunotherapy and the targeting of intracellular signalling molecules involved in the pathogenesis of pemphigus are needed.

language: English


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