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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2008 June;143(3):181-5
Cutaneous sarcoidosis in Tunisia
Khaled A. 1, Souissi A. 1, Zeglaoui F. 1, Mokhtar I. 2, Ezzine N. 1, Fazaa B. 1, Kamoun M. R. 1
1 Department of Dermatology Charles Nicolle Hospital, Tunis, Tunisia
2 Department of Dermatology Habib Thameur Hospital, Tunis, Tunisia
Aim. Sarcoidosis is a multisystem disease of unknown etiology characterized by granulomatous infiltration. As clinical features vary among patients from different ethnic groups and geographic areas, local reports are of great interest. The aim of this study was to make an inventory of the clinical presentation of cutaneous sarcoidosis in Tunisia.
Methods. The study was conducted in an academic teaching hospital, inpatient and outpatient department. The authors retrospectively reviewed the medical records of all patients diagnosed with sarcoidosis at the Dermatological Departement of Charles Nicolle teaching Hospital, Tunis, within a 32-year period.
Results. One hundred and eighteen patients were diagnosed to have sarcoidosis, corresponding to 25 males and 93 females. Mean age at presentation was 39.5 years. Childhood sarcoidosis represented 14.4% of cases. Cutaneous involvement was dominated by micronodular lesions. Chest X-rays abnormalities were present in 28 patient/93 (30.1%). Most of them were at stage 1 or 2. Peripheral lymph node enlargement was reported in 15 patients (12.7%). Other internal organ involvements corresponded to: eyes (15 cases); bones (12 cases), joints (5 cases), gasto-intestinal tract (5 cases), upper airways (5 cases), liver (4 cases), kidney ( 1 case) and muscles (1 case). Systemic involvement was noticed in 88% patients with lupus pernio. Treatment modalities included topical and oral corticosteroids, hydroxychloroquine, allopurinol and surgical excision with variables outcomes.
Conclusion. The data of this study suggest that sarcoidosis manifests with a wide range of cutaneous lesions in Tunisian patients and that extracutaneous involvement is not rare. Remarkable clinico-epidemiological characteristics are the clear predominance in women, the high frequency of childhood cases and the predominance of micronodular skin lesions.