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A Journal on Dermatology and Sexually Transmitted Diseases

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2007 October;142(5):533-45

language: English

Murine transgenic models that mimic psoriasis

Ayli E. E. 1, Nickoloff B. 2, Seykora J. T. 1

1 Department of Dermatology University of Pennsylvania School of Medicine Philadelphia, PA, USA
2 Department of Pathology Loyola University of Chicago Medical Cente Maywood, IL, USA


Psoriasis is a uniquely human disease that has been recognized since the time of Hippocrates (460-377 B.C.). It is a common, yet complex, autoimmune skin disease that is mediated by T-cells resulting in altered keratinocyte growth. In order to better understand psoriasis, much research has been conducted to identify genetic loci and cellular proteins associated with psoriasis; such information has led to the development of in vivo murine models of psoriasis. In this review, we discuss the various transgenic mouse models that mimic psoriasis and, whenever possible, draw parallels between these models and human disease. Considering the complexity of psoriatic pathophysiology and the differences between murine and human immune systems, a systematic approach must be taken when comparing murine models to the human standard. Investigators have proposed a systematic method for comparing features of psoriasis with correlates in murine models of the disease. One such grading schema examines the clinical, histologic, immunophenotypic, biochemical, pharmacologic, and genetic features of murine models and derives a score based on a one-hundred point system; this method has been termed the Psoriatic Animal Model Validation Index (PAMVI). In this review, we utilize the PAMVI grading method to determine the strengths and weaknesses of the various murine models. Implementation of such a grading scheme allows a rigorous comparison between human psoriasis and transgenic mouse models, and could advance psoriasis research by focusing work on relevant transgenic models of psoriasis.

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