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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2007 June;142(3):243-9
Immunological aspects of atopic dermatitis
Silny W., Czarnecka-Operacz M.
Department of Dermatology K. Marcinkowski Medical University Poznan´, Poland
Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin disease involving epidermis and dermis. It is highly pruritic and skin lesions present typical eczematous morphology as well as characteristic localizations. AD is often associated with other atopic diseases. The pathophysiology of AD includes a genetic predisposition, impaired skin barrier function, frequent allergic responses to common environmental allergens and defects in the antimicrobial immune defense. This review presents basic advances in the understanding of immunological aspects of AD.