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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2006 December;141(6):483-93
Allergic contact dermatitis. A review of immunological mechanisms
Hunger R. E., Hassan A. S., Braathen L. R., Yawalkar N.
Department of Dermatology University of Berne Inselspital, Bern, Switzerland
Allergic contact dermatitis is a T cell mediated, antigen-specific inflammatory reaction of the skin due to repeated epicutaneous exposure to antigens. Immunologically it is divided into 2 phases, induction and elicitation phase. During the first phase which is clinically silent, naïve T cells are activated and differentiate into antigen-specific memory T cells. During the elicitation phase, after recontact with the same antigen, memory T cells are activated and exert direct and indirect cytotoxic effects towards cells of the skin. In this review we summarize immunological mechanisms leading to allergic contact dermatitis.