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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2006 August;141(4):297-302
Dermoscopic patterns as predictors of sentinel lymph node metastasization in cutaneous melanoma
Curci M., Pellacani G., Magnoni C., Fantini F., Cimitan A., Seidenari S.
Department of Dermatology University of Modena and Reggio Emila, Modena, Italy
Aim. Dermoscopic criteria are associated with histological equivalents, showing that surface microscopy can also be helpful for prognostic purposes, and particularly for the preoperative assessment of melanoma thickness. In order to assess the association between peculiar dermoscopic features and the degree of aggressiveness of the tumour in terms of probability of lymphatic metastasization, melanomas with positive and negative sentinel lymphnode were retrospectively evaluated by means of dermoscopic examination.
Methods. The images acquired by means of a digital dermatoscope of 101 melanomas which underwent sentinel lymph node biopsy were described for dermoscopic features and semiquantitative algorithms, such as the ABCD rule and the new 7-point checklist.
Results. Melanomas with negative lymph nodes more frequently showed irregularly distributed network, hypopigmented areas, also corresponding to regression areas, and thin blood vessels, whereas the presence of structureless areas and grey-blue areas, together with a lower ABCD score, were associated with lymphnodal metastases.
Conclusions. Even if surface microscopy alone is reasonably not sufficient to predict sentinel lymph node involvement with high accuracy, some peculiar dermoscopic features appear associated to higher risk of locoregional metastases.