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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2006 April;141(2):99-106
NM23 protein expression in primary melanoma correlates with disease-free interval and with survival: a ten-year follow-up study
Ferrari D. 1, Lombardi M. 1, Ricci R. 2, Michiara M. 3, Pedrazzi G. 4, Santini M. 1, De Panfilis G. 1
1 Unit of Dermatology, Department of Surgical Sciences University of Parma, Parma, Italy
2 Unit of Pathology Department of Pathology and Laboratory Medicine University of Parma, Parma, Italy
3 Unit of Medical Oncology, Department of Medicine Parma Hospital, Parma, Italy
4 Unit of Physics, Department of Public Health University of Parma, Parma, Italy
Aim. nm23 is considered a metastasis suppressor gene for some human cancers. Decreased expression of nm23 mRNA was found in several metastases of melanoma, and such a lower expression in metastases correlated to the patient’s shortened survival. Since the prognostic role of the expression of NM23 protein in primary melanoma is controversial, the aim of this study was to determine the utility of NM23 protein as an immunohistochemical indicator of prognosis in patients affected with primary melanoma.
Methods. The expression of NM23 protein was analysed in 30 primary skin melanomas. NM23 protein was detected on paraffin sections using an immunoperoxidase technique. The follow-up period included evaluation of the disease-free interval at 5 and 10 years and of the survival outcome at 5 and 10 years.
Results. We found that: 1) expression of NM23 protein correlated positively with disease-free interval within 5 years (P<0.01) and 10 years (P<0.01); 2) expression of NM23 protein correlated positively with survival within 5 years (P<0.01) and 10 years (P<0.01).
Conclusion. In this study, NM23 protein correlates inversely with melanoma progression. However, clinical trials including larger numbers of patients should be performed to confirm the favourable prognostic role of NM23 in melanoma.