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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2006 February;141(1):29-31
Efficacy and tolerability of terbinafine in children
Pau M., Aste N., Aste N.
Department of Dermatology University of Cagliari, Cagliari, Italy
Aim. Dermatomycoses in children are very frequent and often require systemic treatment. We report our experience on the efficacy and tolerability of terbinafine in a group of children.
Methods. Fifty children between 2 and 14 years of age, 22 of whom suffering from tinea capitis and 28 from tinea corporis, widespread and/or with hair involvement, were treated with terbinafine. Doses employed were 62.5 mg/day in patients weighing less than 20 kg, 125 mg/day between 20 and 40 kg, 250 mg/day in patients weighing more than 40 kg. Treatment periods ranged between 2 and 12 weeks based on clinical symptoms. Clinical and mycological tests were performed at weekly intervals in children affected by tinea corporis and every 2 weeks in those with tinea capitis for the whole period of treatment and 4 weeks after the end of treatment.
Results. Overall clinical and mycological recovery was achieved in 45 children (or 90% of cases): 18 cases of tinea capitis and 27 of tinea corporis. In patients affected by tinea capitis from Microsporum canis treatment duration was 12 weeks and healing was achieved in 16 cases out of 20. In the 2 children with tinea capitis from Tricophyton mentagrophytes, healing was achieved after 6 weeks’ treatment.
Conclusion. Terbinafine is a highly effective drug for the treatment of skin fungal infections in children. As regards tinea capitis from Microsporum canis additional studies are needed to better standardize dosage and treatment cycles.