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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2005 August;140(4):407-16
The histologic diagnosis of early mycosis fungoides: frequent problems, sporadic solutions
Glusac E. J.
Department of Pathology and Dermatology Yale University School of Medicine, New Haven, CT, USA
Recent advances in the diagnosis of mycosis fungoides, including T cell receptor gene rearrangement studies, have improved our ability to diagnose this challenging condition. However, it is clear that clonality alone does not equate with malignancy. Despite the aide of ancillary studies, mycosis fungoides remains one of the most difficult dermatologic diagnoses to establish. The histopathologic diagnosis of mycosis fungoides remains within the realm of clinical/histologic/molecular correlation. As such, histologic analysis of early mycosis fungoides remains a key factor in the diagnosis of this challenging condition. It is well known that mycosis fungoides can mimic and be mimicked by a variety of other dermatologic conditions, most of which are inflammatory. A wide variety of studies have well characterized the histologic findings of mycosis fungoides, however, we know much less about which histologic criteria are most specific for this disorder. This article will address myriad of difficulties encountered in the histopathologic diagnosis of mycosis fungoides and then review individual criteria used to establish this disorder, with emphasis on criterion specificity.