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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2005 June;140(3):221-7
language: English, Italian
Photodynamic therapy with topical d-aminolaevulinic acid for the treatment of plantar warts
Procaccini E. 1, Fabbrocini G. 2, Lo Presti M. 2, Battimiello V. 2, Delfino M. 2, Monfrecola G. 1
1 Unit of Dermatology ASL Napoli 1, Naples, Italy
2 Unit of Dermatology Department of Systematic Pathology Federico II University of Naples, Naples, Italy
Aim. Treatments currently employed for plantar warts (PW) are often painful and poorly effective. This study evaluates the effect of photodynamic therapy (PDT) with topical d-aminolaevulic acid (ALA) on PW.
Methods. Before treatment, the superficial hyperkeratotic layer of warts was removed by the application, for 7 days, of an ointment containing 10% urea and 10% salicylic acid. Then, after gentle curettage, a cream containig 20% ALA was applied under occlusive dressing for 3 h on 30 patients with 84 warts, while 30 patients with 62 warts (controls) received only base cream. Both groups were irradiated using a visible light lamp (range 400-700 nm, peaking at 630 nm). The light dose was 50 J/cm2 each session. Patients were followed-up for 12 months. During the treatment some patients referred mild burning sensation or a slight pain. The absorption of ALA in warts was investigated and demonstrated by in vivo fluorescence spectroscopy.
Results. Two months after the last irradiative session, 84.5% of the ALA-PDT treated lesions and 22.5% of controls had resolved.
Conclusion. The results of this study suggest that topical ALA-PDT can be considered as alternative treatment for PW.