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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2005 June;140(3):221-7

Copyright © 2005 EDIZIONI MINERVA MEDICA

language: English, Italian

Photodynamic therapy with topical d-aminolaevulinic acid for the treatment of plantar warts

Procaccini E. 1, Fabbrocini G. 2, Lo Presti M. 2, Battimiello V. 2, Delfino M. 2, Monfrecola G. 1

1 Unit of Dermatology ASL Napoli 1, Naples, Italy 2 Unit of Dermatology Department of Systematic Pathology Federico II University of Naples, Naples, Italy


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Aim. Treatments currently employed for plantar warts (PW) are often painful and poorly effective. This study evaluates the effect of photodynamic therapy (PDT) with topical d-aminolaevulic acid (ALA) on PW.
Methods. Before treatment, the superficial hyperkeratotic layer of warts was removed by the application, for 7 days, of an ointment containing 10% urea and 10% salicylic acid. Then, after gentle curettage, a cream containig 20% ALA was applied under occlusive dressing for 3 h on 30 patients with 84 warts, while 30 patients with 62 warts (controls) received only base cream. Both groups were irradiated using a visible light lamp (range 400-700 nm, peaking at 630 nm). The light dose was 50 J/cm2 each session. Patients were followed-up for 12 months. During the treatment some patients referred mild burning sensation or a slight pain. The absorption of ALA in warts was investigated and demonstrated by in vivo fluorescence spectroscopy.
Results. Two months after the last irradiative session, 84.5% of the ALA-PDT treated lesions and 22.5% of controls had resolved.
Conclusion. The results of this study suggest that topical ALA-PDT can be considered as alternative treatment for PW.

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