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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

A Journal on Dermatology and Sexually Transmitted Diseases


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2005 April;140(2):143-7

language: English, Italian

A case of annular elastolytic giant cell granuloma in not sun-exposed skin

Rubegni P., Sbano P., Risulo M., Fimiani M.

Section of Dermatology Department of Clinical Medicine and Immunological Sciences University of Siena, Siena, Italy


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Annular elastolytic giant cell granuloma (AEGCG) is a granulomatous skin disease more common in sun-exposed skin. The histological feature is characterized by phagocytosis of elastic fibers by multinucleate giant cells. The etiopathogenesis of the disease is unclear. However, on the basis of the frequent manifestations on sun exposed skin, it was hypothesised that UV radiation may cause a mutation of elastic fibers in the dermis, triggering an immune-mediate response by T lymphocytes. We report the case of a 45-year-old woman with a 12-month history of annular plaques on the abdomen that met the clinical and histological criteria of AEGCG. The pathogenesis of the disease is discussed on the basis of this unusual localization.

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