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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
A Journal on Dermatology and Sexually Transmitted Diseases
Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,014
Giornale Italiano di Dermatologia e Venereologia 2004 December;139(6):507-14
language: English, Italian
Risk developing a new basal cell carcinoma or other skin neoplasms in patients already treated for a basal cell carcinoma
Di Landro A., Zaccaria E., Naldi L. e Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED)
Department of Dermatology, Milano-Bicocca University Ospedali Riuniti, Bergamo, Italy
Aim. Basal cell carcinoma (BCC) is the most frequent neoplasm in Caucasian population; patients with a history of BCC are considered to be at risk of developing a subsequent BCC or another cancer of the skin. The purpose of this study was to evaluate the risk in a group of Italian patients with a history of a first BCC.
Methods. The group was composed of 322 patients (143 female, 179 male), with a mean age of 68.43 years, already treated for BCC In the period 1994-96. The median follow-up period was 6.1 years.
Results. A second BCC occurred during the study period in 37.5% of the subjects. Men were at higher risk than women. The risk increased after the age of 40 with a peak after 60 years.The second BCC was localised in the same site as the first BCC. A total of 36 (11.2%) subjects had another precancerous disease or skin cancer (Actinic keratosis, Bowen’s disease or squamous cell carcinoma, melanoma); 85% of the patients with multiple BCC developed a second BCC. Patients with a history of BCC are at higher risk of developing another BCC or another skin cancer.
Conclusion. Our data confirm the results of experiences carried out in very different populations. A long term follow-up is necessary, especially during the first years after excision and in patients with an age over 60. The group which developed 2 or more BCC should be checked more frequently.